Table 1.
Summary of spliced Na v exons that are known to affect channel kinetics. Predicted influence on neuron excitability due to splicing are stated, increased (↑), decreased (↓), or complex (?)
| Channel | Exon | Expression system | Predicted effect on cell excitability (by changing) | References |
|---|---|---|---|---|
| DmNa v | J, E | Xenopus oocytes | ↓ (act →) | [15] |
| DmNa v | F | Xenopus oocytes | ↑ (act ←) | [15] |
| DmNa v | H | Xenopus oocytes | ↑ (inact →) | [15] |
| DmNa v | K | Xenopus oocytes | ↓ (INaP amplitude ↓) | [15] |
| DmNa v | L | Xenopus oocytes | ↑ (INaP amplitude ↑) | [15] |
| hNa v 1.1 | 5A | HEK293T | ↑ (INaP amplitude ↑, inact →) | [61] |
| hNa v 1.1 | 5N | HEK293T | ↓ (INaP amplitude ↓, inact ←) | [61] |
| hNa v 1.3 | 12v1 | Xenopus oocytes | ↓ (inact ←) | [30] |
| hNa v 1.3 | 12v2 | Xenopus oocytes | ↓ (act →) | [30] |
| hNa v 1.3 | 12v3 | Xenopus oocytes | ↑ (inact →) | [30] |
| hNa v 1.3 | 12v4 | Xenopus oocytes | ↑ (act ←) | [30] |
| BgNa v | B | Xenopus oocytes | ↑ (INaT amplitude ↑) | [28] |
| BgNa v | G1 | Xenopus oocytes | ? (INaT amplitude ↓, act ←, inact →) | [20] |
| BgNa v | G2 | Xenopus oocytes | ? (INaT amplitude ↑, act →, inact ←) | [20] |
Specific changes observed to channel kinetics are as follows: depolarising (→) or hyperpolarising (←) shifts in activation (act) or inactivation (inact) and/or increased (↑) or decreased (↓) transient (INaT) or persistent sodium current (INaP) amplitude