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. 2014 Dec;351(3):485–491. doi: 10.1124/jpet.114.219337

Fig. 5.

Fig. 5.

Tolerance to DOI-elicited head twitch behavior is not surmounted by a higher DOI dose. Filled circles represent mice treated with saline on days 1–3 and tested with various DOI doses on day 4, whereas open circles represent mice treated with 1.0 mg/kg DOI on days 1–3, and then tested with various DOI doses on day 4. Asterisks indicate significant differences (P < 0.05) from HTR elicited by saline administration, whereas hash marks indicate significant differences (P < 0.05) from saline-treated for each DOI test dose. The abscissa is as described in Fig. 2. The ordinate is as described in Fig. 2. IP, intraperitoneal; SAL, saline.