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Cross-tolerance to head twitch behavior is observed in mice treated with 1.0 mg/kg DOI on days 1–3, and then tested with various doses of 2C-T-7 (left) or DPT (right) on day 4. As with DOI itself (Fig. 5), cross-tolerance is insurmountable with increasing 2C-T-7 or DPT dose. All other graph properties are as described in Fig. 5. *P < 0.05; #P < 0.05. IP, intraperitoneal; SAL, saline.
