Fig. 2.

The group-by-age interaction in the ACC (A). Partial regression plot showing the between-group relationship with age, covarying for gender. The values shown on x- and y-axes respectively represent residualised age and residualised average GMV (B). Post-hoc within-group partial regression with self-reported depression severity, covarying for age and gender. The values shown on x- and y-axes respectively represent residualised depression scores and residualised average GMV. Adolescents with MDD showed no significant correlation between GMV in the ACC region and severity of depression (r = −0.03, p = 0.77) (C). Each plot also includes 95% confidence intervals.