Table 1.
Major sequencing studies.
| Stransky | Agrawal | Pickering | India ICGC |
|
|---|---|---|---|---|
| N | 74 | 32 | 40 | 50 |
| Disease sitesa | OC, OP, H, L, SC | OC, OP, L, H | OC | OC |
| Smokers | 89% | 75% | 78.6% | 96% |
| HPV positivity | 14% | 25% | 2.5% | 26% |
| Mean coverage | 150 | 77d | 119 | 38d |
| Whole exome | 72 | 32 | 40 | 50 |
| Whole genome | 2 | 0 | 0 | 0 |
| Additional tumors with limited sequencing | NA | 88 | NA | 60 |
| Significantly mutated genesb | 39 | 6 | 53 | 10 |
| Mutations per MB (HPV+; HPV−) | 2.28; 4.83 | 4.8; 20.6 | NRc | 4.07; 3.36 |
a
Sites: OC: Oral Cavity, OP: Oropharynx, H: Hypopharynx, L: Larynx; SC sinonasal cavity.
b
Significantly mutated here is as determined by authors of paper (some studies included formal statistical testing, while others did not).
c
Not reported.
d
Group used multiple sequencing platforms, highest mean coverage is reported.