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. 2015 Jan 24;15:1. doi: 10.1186/s12906-015-0520-z

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© Sheu et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Regulatory mechanisms of Epas1 expression in articular cartilage explants under IL-1β treatment. In this study, mouse articular cartilage explants are treated with IL-1β cytokines. The results showed that IL-1β can enhance Epas1 gene expression (A), and suppress collagen type II (Col2a1) gene expression (B). The pretreatment of 10−8M Ecd can effectively eliminate the Epas1 gene expression enhanced by IL-1β treatment. (Each value is the mean ± standard deviations; n = 8; *:p<0.05; **:p< 0.01; ***:p < 0.001).