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Ecd pre-treatment reduce the catabolic effect of IL-1β on the cartilage explants. Treatment of primary cultures of mouse articular cartilage explants with recombinant mouse IL-1β protein specifically induce the expression of MMP3 (A), MMP13 (B) and ADAMTS-5 (C) genes expression; with the pretreatment of 10−8M Ecd, the catabolic factor genes upregulated by IL-1β treatment are eliminated. (Each value is the mean ± standard deviations; n = 8; *:p<0.05; **:p< 0.01; ***:p < 0.001).
