Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jan 24;15:1. doi: 10.1186/s12906-015-0520-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Sheu et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Ecd protect cartilage explants both in hypoxic and normoxic conditions. The Epas 1 gene expression is enhanced under hypoxic condition. With the pre-treatment of 10−8M Ecd, it can effectively eliminate the IL-1β enhanced Epas1 gene expression (A). The Col2a1 gene expression was stationary under normoxic condition (B). Under hypoxic condition, the pretreatment of 10−8M Ecd can effectively eliminate the IL-1β down-regulated Col2a1 gene expression. Under hypoxic condition, IL-1β mediates HIF-2α–induced ADAMTS-5 gene expression of articular cartilage. The pretreatment of 10−8M Ecd can effectively down-regulate MMP3 gene expression only under normoxic condition (C); while down-regulate ADAMTS5 genes expression both in normoxic and hypoxic conditions (D). (Each value is the mean ± standard deviations; n = 8; *:p<0.05; **:p< 0.01; ***:p < 0.001).