Table 1.
Nomenclature for BTM. Based on recommendations of the Committee of Scientific Advisors of the International Osteoporosis Foundation.2
| BTM | Abbreviation | Comment |
|---|---|---|
| Bone formation markers | ||
| Osteocalcin | OC | |
| Undercarboxylated osteocalcin | ucOC | |
| Total osteocalcin | Total OC | Intact [OC (1–49)] + N-mid fragment [OC (1–43)] |
| Alkaline phosphatase | ||
| Total alkaline phosphatase | Total ALP | Bone + liver + other sources |
| Bone alkaline phosphatase | Bone ALP | |
| Procollagen type I N propeptide | PINP | Also called N-terminal extension peptide of type I collagen |
| Intact procollagen type I N propeptide | Intact PINP | Refers to the trimer of two pro-α1 chains and one pro-α2 chain |
| Monomer of procollagen type I N propeptide | mon PINP | Thought to be a single pro-α1 chain |
| Total procollagen type I N propeptide | Total PINP | Monomer + trimer |
| Bone resorption markers | ||
| Deoxypyridinoline | DPD | Total or free |
| N-terminal cross-linking telopeptide of type I collagen | NTX-I | In publications concerning bone, the ‘I’ can be omitted |
| C-terminal cross-linking telopeptide of type I collagen | CTX-I | β (beta) isomerised unless otherwise specified In publications concerning bone, the ‘I’ can be omitted |
| Tartrate-resistant acid phosphatase | TRACP5b | Bone specific isoform of acid phosphatase secreted by osteoclast |