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. 2015 Jan 28;5:7922. doi: 10.1038/srep07922

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Stage 1: Set threshold values to collect the differentially expressed (upregulated and downregulated) miRNAs and mRNAs. Stage 2: Determine the corresponding GO terms, KEGG pathways and particular miRNAs that are enriched for the target genes. Stage 3: Determine the predicted miRNAs-genes using algorithms and confirm these results using correlation analysis. Stage 4: Integrate the experimentally validated miRNA targets, interacting proteins and predicted miRNAs-genes to build functional networks. Stage 5: Identify highly connected modules within the global networks and then perform GO term and KEGG analyses.