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. 2015 Jan 13;2015:530371. doi: 10.1155/2015/530371

Figure 2.

Figure 2

Effect of dexmedetomidine on hyperoxia-modified GSH and GSSG levels in the developing brain. (a) Reduced GSH levels were evident in total rat brain extracts 24 h after the initiation of hyperoxia (black bar) when compared to normoxic animals (white bar). These levels were increased through dexmedetomidine (DEX) pretreatment in a concentration dependent manner (hatched grey bars: 1, 5, and 10 μg/kg). (b) Increased levels of oxidized GSSG were obvious in total brain extracts at 24 h of hyperoxia (black bar) when compared with normoxic control animals (white bar). These levels were decreased through pretreatment with DEX (hatched grey bars: 1, 5, and 10 μg/kg). (c) Reduced GSH/GSSG ratio levels were evident in rat brain extracts at 24 h of hyperoxia (black bar) when compared to normoxic control animals (white bar). These levels were upregulated through DEX pretreatment (hatched grey bars: 1, 5, and 10 μg/kg). Application of dexmedetomidine under room air (grey bars) showed no effect on GSH or GSSG levels. Bars represent mean + SEM; n = 6 per group; *** P < 0.001 versus normoxia/control; ### P < 0.001 versus hyperoxia.