Table 1.

In vitro permeation studies of different concentrations of aceclofenac in aqueous solution through excised goat, sheep, and buffalo corneas.

Conc. % (w/v)	Amount permeated (mg) (120 minutes)			Permeation (%) (120 minutes)			Corneal hydration (%)			Papp cm/sec ∗ 106
	Goat	Sheep	Buffalo	Goat	Sheep	Buffalo	Goat	Sheep	Buffalo	Goat	Sheep	Buffalo
0.1	1.006 ± 0.005	0.944 ± 0.002	0.789 ± 0.004	98	94.4	78.90	80.2 ± 0.582	80.7 ± 0.001	80.2 ± 0.68	13.81 ± 0.2	12.06 ± 0.02	10.15 ± 0.1
0.2	1.8 ± 0.0012	1.6 ± 0.003	1.62 ± 0.001	90	80	81	80.5 ± 0.021	80.5 ± 0.245	79 ± 0.366	11.55 ± 0.1	10.27 ± 0.1	10.3 ± 0.8
0.3	2.05 ± 0.004	1.96 ± 0.001	1.87 ± 0.003	68.33	65.5	62.4	80.1 ± 0.187	80.9 ± 0.548	80.4 ± 0.366	9.15 ± 0.02	8.78 ± 0.4	8.42 ± 0.6
0.4	2.43 ± 0.006	2.36 ± 0.002	2.24 ± 0.001	60.75	59	56.0	80.4 ± 0.456	80.1 ± 0.216	77 ± 0.325	7.89 ± 0.8	8.41 ± 0.3	7.24 ± 0.2
0.5	2.73 ± 0.001	2.64 ± 0.005	2.58 ± 0.008	54.6	52.8	51.6	79.2 ± 0.213	81.2 ± 0.658	79.3 ± 0.39	7.24 ± 0.12	7.00 ± 0.2	6.8 ± 0.4

Values are mean ± SE of three corneas in each group. Statistically significant (P < 0.05) determined by one-way ANOVA followed by Dunnett's test.

Note: All the experiments were carried out in triplicates.