Table 3.
In vitro relative permeation characteristics of aceclofenac from control and optimized formulation through excised goat, sheep, and buffalo corneas.
| Animal |
Thickness of cornea mm |
Control formulation |
Optimized formulation BAC benzalkonium chloride |
||||
|---|---|---|---|---|---|---|---|
| Amount permeated (mg) (120 minutes) | Permeation (%) (120 minutes) | Papp cm/sec ∗ 106 | Amount permeated (mg) (120 minutes) | Permeation (%) (120 minutes) | Papp cm/sec ∗ 106 | ||
| Goat | 0.68 ± 0.0003 | 2.8 ± 0.002 | 56 | 9.998 ± 0.86 | 4.4 ± 0.004 | 84 | 15.01 ± 0.45 |
| Sheep | 0.86 ± 0.0003 | 1.2 ± 0.009 | 24 | 3.36 ± 0.12 | 2.8 ± 0.008 | 76 | 9.60 ± 0.03 |
| Buffalo | 1.12 ± 0.0006 | 1.1 ± 0.004 | 22 | 2.99 ± 0.36 | 1.7 ± 0.005 | 34 | 4.91 ± 0.21 |
Values are mean ± SE of three corneas in each group. Statistically significant (P < 0.05) determined by one-way ANOVA followed by Dunnett's test.
Note: All the experiments were carried out in triplicates.