Table 2.
Effect of Piper cubeba ethanolic extract on liver markers in CCl4-induced hepatotoxicity.
| Treatments | Dose mg/kg | SGOT (U/L) | SGPT (U/L) | GGT (U/L) | ALP (U/L) | Bilirubin (mg/dL) | LDH (U/L) |
|---|---|---|---|---|---|---|---|
| Normal | 87.28 ± 4.15 | 31.96 ± 3.05 | 4.90 ± 0.32 | 318.50 ± 6.34 | 0.52 ± 0.02 | 91.72 ± 3.81 | |
| CCl4 | 1.25 mL/kg | 222.33 ± 15.57∗∗∗a | 164.83 ± 9.08∗∗∗a | 16.18 ± 0.93∗∗∗a | 471.16 ± 12.03∗∗∗a | 2.36 ± 0.05∗∗∗a | 172.68 ± 8.08∗∗∗a |
| PCEE + CCl4 | 250 | 218.00 ± 6.91b | 166.16 ± 9.61b | 14.16 ± 0.41b | 410.00 ± 8.89∗∗b | 1.84 ± 0.08∗∗∗b | 160.34 ± 6.08b |
| PCEE + CCl4 | 500 | 154.00 ± 6.71∗∗b | 120.10 ± 8.41∗∗b | 12.05 ± 0.38∗∗b | 364.50 ± 12.20∗∗∗b | 1.53 ± 0.05∗∗∗b | 139.59 ± 4.21∗∗b |
| Silymarin + CCl4 | 10 | 137.83 ± 5.85∗∗∗b | 96.66 ± 5.99∗∗∗b | 9.33 ± 0.22∗∗b | 355.50 ± 13.97∗∗∗b | 0.92 ± 0.05∗∗∗b | 117.02 ± 3.65∗∗∗b |
All values represent mean ± SEM. ** P < 0.01; *** P < 0.001; a P < 0.05; b P < 0.01; c P < 0.001 ANOVA, followed by Dunnett's multiple comparison test.
∗,∗∗,∗∗∗Compared to normal group; a,b,ccompared to CCl4 only group.