Table 2.
Distribution of cases and controls, odds ratiosa (OR), and 95% confidence intervals (CI) for hepatocellular carcinoma (HCC) according to selected polymorphisms.
| HCC cases (N = 221) | Controls (N = 290) | OR (95% CI) | |||
|---|---|---|---|---|---|
| N | (%) | N | (%) | ||
| CYP1A1 * 2A | |||||
| wt/wt | 165 | (74.7) | 226 | (77.9) | 1b |
| wt/mt and mt/mt | 56 | (25.3) | 64 | (22.7) | 1.21 (0.80–1.84) |
| CYP2E1 * 5B | |||||
| c1/c1 | 217 | (98.2) | 270 | (93.1) | 1b |
| c1/c2 and c2/c2 | 4 | (1.8) | 20 | (6.9) | 0.23 (0.06–0.71) |
| CYP2E1 * 6 c | |||||
| wt/wt | 204 | (99.0) | 261 | (90.0) | 1d |
| wt/mt and mt/mt | 2 | (1.0) | 29 | (10.0) | 0.08 (0.01–0.33) |
| GSTM1 c | |||||
| Present | 96 | (47.8) | 139 | (48.1) | 1b |
| Null | 105 | (52.2) | 150 | (51.9) | 0.99 (0.68–1.43) |
| GSTT1 c | |||||
| Present | 141 | (70.1) | 220 | (76.1) | 1b |
| Null | 60 | (29.9) | 69 | (23.9) | 1.35 (0.89–2.05) |
| SULT1A1 | |||||
| wt/wt | 132 | (59.7) | 180 | (62.1) | 1b |
| wt/mt and mt/mt | 89 | (40.3) | 110 | (37.9) | 1.22 (0.84–1.77) |
aAdjusted for age and sex.
bReference category.
cThe sum does not add up to the total because of some missing values.
dCalculated from exact logistic regression analysis.
wt: wild-type allele.
mt: variant-type allele.