(a).
| Number | First author | Concurrent therapy | Adjunctive agent (mg/day, daily max. dose) |
Duration (weeks) | n (drop) | Primary outcome | Secondary outcome | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Weight reduction | Mean outcome | Mean difference | P | Psychiatric evaluation | Mean baseline | Mean change | P | ||||||
| 2 | Narula (2010) [9] | Olanzapine | Topiramate (100) placebo |
12 | 33 (3) 34 (2) |
BMI (kg/m2) | 20.1 22.6 |
−2.5 | 0.004 | PANSS | 102.9 103.8 |
−71.7 −70.5 |
0.001 |
|
| |||||||||||||
| 3 | Afshar (2009) [10] | Clozapine | Topiramate (300) placebo |
8 | 16 (0) 16 (0) |
BMI (kg/m2) | 23.2 25.4 |
−2.19 | ≤0.05 | PANSS | 96.9 101.9 |
−20 −1.3 |
<0.001 |