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Possible combinations of 20S proteasome core with proteasome activator complexes. The 19S (PA700) regulatory cap can associate at one or both ends of the 20S proteasome core to form an asymmetric 26S proteasome or a 26S proteasome, respectively. The IFN-γ-induced 11S (PA28) regulatory complex can bind at the free end of a 19S-20S complex to form a hybrid proteasome, or it can associate with both ends of the 20S immunoproteasome core.
