Table 2.
Relative bioavailability of everolimus one 5 mg tablet versus five 1 mg tablets (PK population, N=22)
| PK parameter | Everolimus dose | Adjusted geometric mean | Treatment comparisona
|
|
|---|---|---|---|---|
| Geometric mean ratio | 90% CI | |||
| AUCinf (ng · h/mL) | 1×5 mg 5×1 mg |
243 264 |
1.08 | 1.02–1.16 |
| Cmax (ng/mL) | 1×5 mg 5×1 mg |
28.7 42.3 |
1.48 | 1.35–1.62 |
Notes:
a
Comparison of everolimus five 1 mg tablets (test) with one 5 mg tablet (reference).
Abbreviations: AUC, area under the concentration–time curve; AUCinf, AUC from time zero to infinity; Cmax, maximum blood concentration; CI, confidence interval; PK, pharmacokinetics.