Table 5.

mRNA Expression of HIFs, Genes With Hypoxia Response Elements, and Genes Involved in Cardioprotection and HIF‐α Stability

	Left Ventricle		Right Ventricle
	Control	PR	Control	PR
Gene
Oxygen sensing
Hif‐1α	0.390±0.035	0.343±0.036	0.348±0.022	0.285±0.018
Hif‐2α	0.389±0.026	0.499±0.083	0.487±0.090	0.387±0.047
Hif‐3α	0.073±0.010	0.061±0.013	0.065±0.006	0.093±0.013
Hif‐1β	0.060±0.010	0.049±0.008	0.056±0.005	0.076±0.010
Angiogenesis
VEGF	0.611±0.054	0.637±0.122	0.436±0.076	0.603±0.065
Flt‐1	0.102±0.009	0.108±0.011	0.115±0.006	0.140±0.012
Ang‐1	0.018±0.002	0.009±0.002*	0.047±0.016	0.019±0.004
Ang‐2	0.016±0.001	0.015±0.003	0.018±0.003	0.021±0.002
Tie‐2	0.075±0.009	0.055±0.011	0.054±0.005	0.085±0.014
Vasodilation
iNOS	0.010±0.002	0.006±0.001	0.006±0.001	0.007±0.001
Adm	0.013±0.001	0.009±0.001*	0.007±0.001	0.006±0.001
Glucose metabolism
GLUT1	0.050±0.006	0.056±0.010	0.042±0.010	0.053±0.009
GLUT3	1.020±0.158	0.931±0.072	1.384±0.327	1.729±0.271
Cardio‐protection
PKCε	0.053±0.006	0.048±0.007	0.072±0.011	0.050±0.008
HIF‐α stability
PHD1	0.081±0.007	0.077±0.006	0.071±0.007	0.072±0.009
PHD2	0.391±0.026	0.344±0.048	0.379±0.029	0.418±0.055
PHD3	0.284±0.020	0.450±0.047*	0.340±0.036	0.436±0.058

Values are mean±SEM (SD). Adm indicates adrenomedullin; Ang, angiopoietin; GLUT, glucose transporter; HIF, hypoxia‐inducible factor; iNOS, inducible nitric oxide synthase; PHD, prolyl hydroxylases; PKCε, protein kinase C‐epsilon; PR, placental restriction; VEGF, vascular endothelial growth factor.

^*P<0.05.