Table 5.
Medication Prescription Rates Before and After Publication of COURAGE in the 90 Days Prior to PCI
| Medication | Total | No. (%), (95% CI) of patients | P‐Value* | |
|---|---|---|---|---|
| Pre‐COURAGE | Post‐COURAGE | |||
| Pre‐PCI | ||||
| Optimal medical therapy | 8023 (33.9%) | 34.9 (34.1 to 35.8) | 32.8 (31.9 to 33.6) | <0.001 |
| Suboptimal medical therapy | 11 891 (50.2%) | 50.0 (49.1 to 50.9) | 50.4 (49.5 to 51.3) | 0.519 |
| None | 3766 (15.9%) | 15.0 (14.4 to 15.7) | 16.8 (16.1 to 17.5) | <0.001 |
| Individual medications | ||||
| Long‐acting nitrate | 5574 (23.5%) | 26.8 (26.0 to 27.6) | 20.2 (19.5 to 21.0) | <0.001 |
| β‐Blocker | 13 467 (56.9%) | 59.3 (58.4 to 60.2) | 54.4 (53.5 to 55.3) | <0.001 |
| Calcium channel blocker | 9177 (38.8%) | 39.1 (38.3 to 40.0) | 38.4 (37.5 to 39.3) | 0.244 |
| Statin | 15 215 (64.3%) | 64.3 (63.5 to 65.2) | 64.2 (63.3 to 65.0) | 0.787 |
| ACE‐I/ARB | 14 762 (62.3%) | 62.7 (61.9 to 63.6) | 61.9 (61.1 to 62.8) | 0.205 |
| Clopidogrel | 5366 (22.7%) | 23.6 (22.8 to 24.3) | 21.7 (21.0 to 22.5) | <0.001 |
| Symptom‐oriented medical therapy | 61.2 (60.6, 61.8) | 63.6 (62.8 to 64.5) | 58.7 (57.8 to 59.6) | <0.001 |
Optimal medical therapy is defined as prescription for β‐blocker, statin, and either ACE inhibitor or ARB in the 90 days prior to PCI. Suboptimal therapy is defined as prescription of at least 1 of the above individual medications. Symptom‐oriented medical therapy is defined as the prescription of any 2 medications from the following in the 90 days pre‐PCI: β‐blocker, long‐acting nitrate, calcium channel blocker or either ACE inhibitor or ARB. ACE indicates angiotensin‐converting enzyme; ARB, angiotensin receptor blocker; COURAGE, Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation; PCI, percutaneous coronary intervention.
McNemar test.