Table 5.
Metabolic and Myocardial Perfusion Indices During PET Before and After Spironolactone (N=11)
| Baseline Median (IQR) | After >6 Months of Spironolactone Median (IQR) | Mean Difference (SD) | P Value* | |
|---|---|---|---|---|
| Kmono, min−1 | 0.041 (0.038 to 0.043) | 0.042 (0.038 to 0.048) | 0.002 (0.002) | 0.001 |
| RPP | 6660 (5858 to 7930) | 6778 (5912 to 7837) | 30.5 (147) | 0.424 |
| Kmono/RPP (×10−6), min−1/beats min per mm Hg | 5.5 (4.8 to 6.6) | 6.4 (5.4 to 7.1) | 0.3 (0.2) | 0.003 |
| Work metabolic index (×106), mL × mm Hg/m2 | 3.4 (2.2 to 3.9) | 5.4 (4.4 to 5.9) | 2.2 (1.3) | 0.001 |
IQR indicates interquartile range; kmono, monoexponential rate of [11C] acetate clearance from left ventricular myocardium; NIDCM, nonischemic dilated cardiomyopathy; RPP, rate pressure product (systolic blood pressure×heart rate).
*
Wilcoxon's signed‐rank test.