Table 4.
Echocardiography of WT, TGSGLT1‐OFF, and TGSGLT1‐ON Mice at 10 and 20 Weeks of Age and TGSGLT1‐ON/OFF Mice at 20 Weeks of Age
| WT | TGSGLT1‐OFF | TGSGLT1‐ON | TGSGLT1‐ON/OFF | |
|---|---|---|---|---|
| 10 weeks | ||||
| N | 7 | 5 | 8 | |
| LVAWT, mm | 0.91±0.05 | 0.80±0.03 | 0.81±0.03 | |
| LVEDD, mm | 2.84±0.12 | 2.79±0.19 | 4.03±0.15†§ | |
| FS, % | 63±2 | 63±4 | 35±4*‡ | |
| HR, bpm | 617±57 | 549±26 | 416±5*§ | |
| 20 weeks | ||||
| N | 5 | 4 | 3 | 4 |
| LVAWT, mm | 0.92±0.06 | 0.93±0.07 | 0.98±0.07 | 0.93±0.08 |
| LVEDD, mm | 3.04±0.20 | 3.01±0.26 | 4.73±0.42†‡ | 3.16±0.10# |
| FS, % | 56±5 | 59±5 | 37±6 | 58±7** |
| HR, bpm | 558±22 | 578±26 | 420±9†§ | 510±29∥** |
FS indicates fractional shortening; HR, heart rate; LVAWT, left ventricular anterior wall thickness; LVEDD, left ventricular end‐diastolic diameter; WT, wildtype.
*P<0.01 relative to same age WT; †P<0.001 relative to same age WT; ‡P<0.05 relative to same‐age TGSGLT1‐OFF; §P<0.01 relative to same‐age TGSGLT1‐OFF; ∥P<0.05 relative to 20‐week‐old TGSGLT1‐ON; #P<0.005 relative to 20‐week‐old TGSGLT1‐ON; **P<0.05 relative to 10‐week‐old TGSGLT1‐ON.