Table 3.
Association of BNP and NT‐proBNP With Cardiovascular Outcomes
| BNP (Quartile IV vs I) | NT‐proBNP (Quartile IV vs I) | |||
|---|---|---|---|---|
| HR* (95% CI) | P Value* | HR* (95% CI) | P Value* | |
| HF | ||||
| Model 1* | 14.79 (7.38 to 29.66) | <0.001 | 26.83 (11.62 to 61.93) | <0.001 |
| Model 2* | 15.21 (7.54 to 30.68) | <0.001 | 25.69 (11.10 to 59.42) | <0.001 |
| Model 3* | 6.33 (1.10 to 4.24) | <0.001 | 9.82 (3.69 to 26.17) | <0.001 |
| Nonfatal MI | ||||
| Model 1* | 3.57 (2.02 to 6.31) | <0.001 | 4.20 (2.02 to 6.31) | <0.001 |
| Model 2* | 3.55 (1.98 to 6.38) | <0.001 | 3.97 (2.17 to 7.26) | <0.001 |
| Model 3* | 2.16 (1.10 to 4.24) | 0.10 | 2.39 (1.15 to 4.96) | 0.04 |
| CVA/TIA | ||||
| Model 1* | 2.42 (1.20 to 4.90) | 0.005 | 3.69 (1.71 to 7.96) | <0.001 |
| Model 2* | 2.46 (1.19 to 5.10) | 0.006 | 3.73 (1.67 to 8.31) | <0.001 |
| Model 3* | 1.84 (0.77 to 4.39) | 0.08 | 3.01 (1.12 to 8.08) | 0.02 |
| CV death | ||||
| Model 1* | 3.66 (2.10 to 6.40) | <0.001 | 7.19 (3.71 to 13.90) | <0.001 |
| Model 2* | 3.90 (2.19 to 6.93) | <0.001 | 6.82 (3.51 to 13.23) | <0.001 |
| Model 3* | 2.17 (1.10 to 4.28) | 0.01 | 3.24 (1.50 to 6.99) | 0.001 |
| Any event | ||||
| Model 1* | 3.09 (2.31 to 4.14) | <0.001 | 4.29 (3.18 to 5.79) | <0.001 |
| Model 2* | 3.36 (2.49 to 4.53) | <0.001 | 4.36 (3.21 to 5.93) | <0.001 |
| Model 3* | 2.02 (1.41 to 2.87) | <0.001 | 2.43 (1.66 to 2.56) | <0.001 |
BNP indicates brain‐type natriuretic peptide; CV, cardiovascular; CVA, cerebral vascular accident; HF, heart failure; HR, hazard ratio; MI, myocardial infarction; NT‐proBNP, amino‐terminal fragment of the BNP prohormone; TIA, transient ischemic attack.
Adjusted for age, sex and ethnicity.
Adjusted for age, natural log of the ratio of total cholesterol to high‐density lipoprotein cholesterol, and diabetes for men and age, natural log of the ratio of total cholesterol to high‐density lipoprotein cholesterol, natural log of systolic blood pressure, diabetes, and smoking for women.
Adjusted for age, sex, ethnicity, diabetes mellitus, current smoking, history of HF, history of MI, body mass index, systolic blood pressure, low‐density lipoprotein, estimated glomerular filtration rate, left ventricular mass index, left ventricular ejection fraction, and left ventricular diastolic function.
P value is for trend across quartiles.