Table 3.

Laboratory Measures Stratified by Study Intervention Group

	N	SHAM	N	RIPC	P Value	P Value*	P Value*
Laboratory investigations at 24 hours
Alanine transaminase, U/L	123	27 (21 to 34)	115	27 (20 to 35)	0.66	0.45
Aspartate transaminase, U/L	123	89 (55 to 137)	114	87 (60 to 130)	0.99	0.15
INR	115	1.5±0.2	107	1.6±0.7	0.15	0.09
Activated partial thromboplastin time, seconds	115	41 (36 to 52)	107	40 (35 to 49)	0.49	0.37
Urea nitrogen, mmol/L	123	5.6 (4.4 to 7.0)	113	5.3 (4.2 to 7.3)	0.74	0.95
Serum creatinine, μmol/L	123	38 (32 to 53)	113	38 (31 to 47)	0.19	0.18
White blood cell count, ×109/L	121	13.4 (10.5 to 15.4)	122	12.8 (9.9 to 16.3)	0.74	0.82
Red blood cell count, ×1012/L	121	3.8±0.8	122	3.8±0.7	0.99	0.82
Hemoglobin, g/L	121	112±21	122	111±21	0.66	0.88
Hematocrit (proportion of 1)	121	0.32 (0.28 to 0.37)	122	0.33 (0.29 to 0.37)	0.33	0.53
Platelets, ×109/L	119	192±61	120	194±66	0.86	0.92
Neutrophils, ×109/L	119	9.2±3.4	118	9.1±3.7	0.66	0.99
Eosinophils, ×109/L	117	0.02 (0.01 to 0.04)	116	0.02 (0.01 to 0.04)	0.36	0.47
Basophils, ×109/L	116	0.02 (0.01 to 0.05)	116	0.03 (0.01 to 0.05)	0.29	0.25
C‐reactive protein, mg/L	123	114±39	121	115±43	0.97	0.79
Cystatin‐C, μg/mL	130	2.23±0.95	122	2.16±0.98	0.57	0.34
Clusterin, μg/mL	130	169±59	122	176±65	0.38	0.19
β2‐microglobulin, μg/mL	130	1.52 (1.08 to 2.19)	122	1.92 (1.41 to 2.72)	0.66	0.37
S100B, pg/mL	131	77 (51 to 115)	117	82 (60 to 130)	0.65	0.92
pNF‐H, ng/mL	113	0.14 (0.09 to 0.19)	108	0.15 (0.08 to 0.21)	0.89	0.50
Laboratory investigations at 48 hours
Alanine transaminase, U/L	53	27 (20 to 40)	48	29 (19 to 35)	0.85	0.66	0.08
Aspartate transaminase, U/L	53	66 (46 to 90)	48	61 (43 to 84)	0.44	0.05	0.92
INR	54	1.4±0.4	49	1.3±0.3	0.39	0.60	0.16
Activated partial thromboplastin time, seconds	54	41 (35 to 51)	49	43.0 (35 to 56)	0.17	0.12	0.24
Urea nitrogen, mmol/L	55	6.3 (4.6 to 8.3)	50	6.2 (5.2 to 7.5)	0.56	0.07	0.27
Serum creatinine, μmol/L	55	34 (29 to 53)	50	35 (28 to 44)	0.08	0.05	0.40
White blood cell count, ×109/L	61	14.0 (10.9 to 15.7)	55	12.8 (8.9 to 15.3)	0.01	0.02	0.17
Red blood cell count, ×1012/L	61	4.0±0.8	55	3.9±0.7	0.70	0.43	0.76
Hemoglobin, g/L	61	117±22	55	116±19	0.72	0.51	0.86
Hematocrit (proportion of 1)	61	0.35±0.07	55	0.35±0.06	0.77	0.61	0.86
Platelets, ×109/L	61	183±53	54	176±65	0.45	0.80	0.30
Neutrophils, ×109/L	60	8.7±3.4	54	7.0±3.3	0.006	0.02	0.11
Eosinophils, ×109/L	57	0.08 (0.03 to 0.16)	48	0.04 (0.01 to 0.12)	0.11	0.51	0.03
Basophils, ×109/L	56	0.05 (0.02 to 0.11)	47	0.03 (0.00 to 0.06)	0.07	0.41	0.07
C‐reactive protein, mg/L	57	108 (72 to 153)	55	102 (82 to 160)	0.98	0.95	0.91
Cyastatin‐C, μg/mL	60	2.43±0.89	56	2.39±0.76	0.77	0.71	0.82
Clusterin, μg/mL	60	197±60	56	187±68	0.37	0.95	0.39
β2‐microglobulin, μg/mL	60	1.92 (1.36 to 2.58)	56	1.84 (1.38 to 2.56)	0.75	0.36	0.69
S100B, pg/mL	62	81 (51 to 114)	53	83 (63 to 113)	0.99	0.41	0.40
pNF‐H, ng/mL	49	0.19 (0.10 to 0.27)	48	0.16 (0.10 to 0.30)	0.51	0.32	0.48

Median (interquartile range), mean±SD. INR indicates international normalized ratio; pNF‐H, phosphorylated neurofilament H; RIPC, remote ischemic preconditioning; SHAM, sham stimulus.

^*Adjusted for propensity score, cross‐clamp time, and surgery Aristotle score.

^*Change between 24 and 48 hours.