Table 3.
Characterization of Right Ventricular Pressure Overload Induced by Severe Pulmonary Artery Constriction in Wild‐Type and Eng+/− Mice
| Wild Type | Eng+/− | |||
|---|---|---|---|---|
| Sham (n=6) | PAC (n=7) | Sham (n=6) | PAC (n=8) | |
| Total body weight, g | 35±2 | 24±2* | 34±4 | 28±2 |
| RV weight/tibial length, g/mm | 1.4±0.1 | 3±0.1* | 1.7±0.3 | 2.3±0.1 |
| LV weight/tibial length, g/mm | 6±0.4 | 4±0.3* | 5±0.2 | 4±0.3*,† |
| Hemodynamic variables | ||||
| RV systolic pressure, mm Hg | 21±6 | 50±4* | 24±3 | 46±9 |
| RV end‐diastolic pressure, mm Hg | 4±2 | 8±4 | 2±1 | 4±2 |
| RV +dp/dt, mm Hg/sec | 2358±392 | 3328±1163* | 2064±343 | 3517±1118* |
| RV −dp/dt, mm Hg/sec | 2514±187 | 2613±849 | 2079±341 | 2715±622* |
| RV stroke volume, μL | 9±3 | 4±1* | 8±2 | 7±1† |
| Cardiac output, mL/min | 5±1 | 2±1* | 4±1 | 4±1† |
| Heart rate, beats per min | 540±62 | 532±51 | 509±13 | 521±24 |
PAC indicates pulmonary artery constriction; LV, left ventricular; RV, right ventricular.
*P<0.01 versus sham; †P<0.01 versus wild‐type PAC.