Table 4.
Characterization of Right Ventricular Pressure Overload Induced by Severe Pulmonary Artery Constriction in Wild‐Type Mice Treated With Either a Neutralizing Antibody Against Endoglin (N‐Eng Ab) or IgG‐Isotype Control Antibody (IgG)
| Wild Type | Wild Type+N‐Eng Ab | |||
|---|---|---|---|---|
| Sham | PAC | Sham | PAC | |
| Total body weight, g | 29±2 | 23±2* | 28±1 | 24±2* |
| RV weight/tibial length, g/mm | 1.5±0.01 | 2.5±0.01* | 1.5±0.01 | 1.9±0.01*,† |
| LV weight/tibial length, g/mm | 6±0.01 | 4±0.01* | 6±0.01 | 5±0.02* |
| Hemodynamic variables | ||||
| RV systolic pressure, mm Hg | 22±3 | 48±4* | 24±3 | 53±9* |
| RV end‐diastolic pressure, mm Hg | 4±1 | 7±4 | 3±2 | 4±2 |
| RV +dp/dt, mm Hg/sec | 2374±429 | 3189±982 | 2171±283 | 4130±563* |
| RV −dp/dt, mm Hg/sec | 2419±304 | 2810±891 | 1963±257 | 3287±350* |
| RV stroke volume, μL | 8±3 | 4±1* | 8±2 | 5±1* |
| Cardiac output, mL/min | 4.3±1 | 1.8±1* | 4.0±1 | 2.4±0.2 |
| Heart rate, beats per min | 538±25 | 548±33 | 512±59 | 541±52 |
PAC indicates pulmonary artery constriction; LV, left ventricular; RV, right ventricular.
*P<0.01 versus sham; †P<0.01 versus wild‐ype PAC (n=6/group).