Table 5.

Characterization of Chronic Right Ventricular Pressure Overload Induced by Moderate Pulmonary Artery Constriction in Wild‐Type Mice Treated With Either a Neutralizing Antibody Against Endoglin (N‐Eng Ab) or IgG‐Isotype Control Antibody (IgG Ab)

	Sham	PAC
		3 weeks	6 weeks+IgG Ab	6 weeks+N‐Eng Ab
Total body weight, g	31±1	27±2*	27±1*	27±2*
RV weight/tibial length, g/mm	1.4±0.5	2.7±0.5*	2.7±0.4*	2.5±0.4*
LV weight/tibial length, g/mm	5.4±0.5	3.5±0.1*	4.1±0.1*	4.5±0.2*
Hemodynamic variables
RV systolic pressure, mm Hg	26±1	70±5*	69±10*	69±14*
RV end‐diastolic pressure, mm Hg	1±1	4±2	2±1	2±1
RV +dp/dt, mm Hg/sec	2212±52	4836±929*	4215±674*	4072±875*
RV −dp/dt, mm Hg/sec	2115±64	4171±278*	4345±818*	3916±875*
RV stroke volume, μL	9±2	3±1*	3±2*	3±2*
Cardiac output, mL/min	4.3±1	1.5±1*	1.3±0.5*	1.4±0.6*
Heart rate, beats per min	500±81	592±83	527±69	550±52

PAC indicates pulmonary artery constriction; LV, left ventricular; RV, right ventricular.

^*P<0.01 versus sham (n=6/group).