Figure 8.

Treatment reduces cardiac Ca²⁺ cycling alterations in HIP rats. A, Mean Ca²⁺ transient amplitude, (B) SR Ca²⁺ content, (C) decay time of Ca²⁺ transient induced by electrical stimulation at 0.5 Hz, and (D) decay time of caffeine‐induced Ca²⁺ transient in cardiac myocytes from WT (15 cells, 4 rats), APAU‐treated WT (17 myocytes, 3 rats), untreated HIP (16 cells, 4 rats), and treated HIP rats (25 cells, 4 rats). *P<0.05, **P<0.01, ***P<0.001 vs untreated WT. #P<0.05 vs treated HIP. APAU indicates (1‐(1‐acetypiperidin‐4‐yl)‐3‐adamantanylurea; HIP, human amylin in the pancreas; SR, sarcoplasmic reticulum; WT, wild‐type.