Figure 3.
Vascular reactivity as measured by ACh‐mediated dilation in femoral arteries of WT (n=7) and angptl2 KD (n=8) mice at 3 to 4 months of age in no‐drug control condition (A) and in the presence of LNNA (100 μmol/L), indomethacin (Indo, 10 μmol/L), or their combination in arteries isolated from WT mice (B) and KD mice (C). The z‐score method followed by the d'Agostino–Pearson omnibus test was used to test normality of data sets, after which the unpaired Student t test (A) and the 1‐way ANOVA followed by the Bonferonni posttest were used (B and C). ‡P<0.05 vs WT; §P<0.05 vs control; ||P<0.05 vs +LNNA. ACh indicates acetylcholine; KD, knockdown; LNNA, Nω‐nitro‐l‐arginine; WT, wild‐type.