Table 7.
Parameters of Fasting Plasma in 6‐Month‐Old WT and Angptl2 KD Mice Fed a Regular Diet (RD) or a 3‐Month High‐Fat Diet (HFD)
| WT | KD | |||
|---|---|---|---|---|
| RD | HFD | RD | HFD | |
| Weight, g | 26.3±0.9 (10) | 33.1±1.4 (9)θ | 24.2±0.5 (13) | 29.0±1.6 (11)‡θ |
| Glucose, mmol/L | 17.0±1.1 (10) | 17.4±1.7 (9) | 13.5±1.1 (12) | 17.1±1.5 (11) |
| Triglycerides, mmol/L | 0.45±0.04 (10) | 0.49±0.05 (9) | 0.41±0.03 (12) | 0.49±0.03 (11) |
| Adiponectin, μg/mL | 8.5±0.4 (5) | 10.1±0.3 (5) | 9.7±1.1 (5) | 8.5±0.7 (5) |
| Leptin, ng/mL | 2.1±0.7 (5) | 20.2±2.1 (5)θ | 2.3±0.5 (5) | 7.5±2.3 (5) |
| FFA, mmol/L | 0.39±0.05 (7) | 0.50±0.05 (5) | 0.39±0.03 (7) | 0.44±0.06 (7) |
| Cholesterol—total, mmol/L | 2.7±0.1 (10) | 3.9±0.2 (9)θ | 2.7±0.2 (12) | 3.9±0.3 (11)θ |
| Cholesterol—HDL, mmol/L | 2.5±0.1 (10) | 3.3±0.1 (9)θ | 2.4±0.2 (12) | 3.5±0.2 (11)θ |
| Cholesterol—LDL, mmol/L | 0.15±0.02 (9) | 0.41±0.11 (8)θ | 0.13±0.01 (12) | 0.25±0.05 (11) |
| Cholesterol—total/HDL | 1.07±0.02 (10) | 1.17±0.03 (9)θ | 1.12±0.02 (12) | 1.12±0.01 (11) |
| LDL/HDL | 0.06±0.01 (9) | 0.12±0.03 (8)θ | 0.06±0.01 (11) | 0.08±0.02 (11) |
| Insulin, ng/mL | 0.10±0.02 (9) | 0.27±0.03 (9)θ | 0.14±0.02 (12) | 0.30±0.08 (10) |
Data presented as mean±SEM of (n) mice. The Kruskal–Wallis test followed by the Dunn's posttest were used for data sets not normally distributed; 2‐way ANOVA followed by the Bonferroni posttest was used to compare normally distributed data sets. FFA indicates free fatty acid; HDL, high‐density lipoprotein; KD, knockdown; LDL, low‐density lipoprotein; WT, wild‐type.
θP<0.05 vs RD (within the same strain); ‡P<0.05 vs WT (within the same treatment).