Table 4.
Effect of Vorapaxar on Overall Occurrences of the Composite Endpoint of CVD, MI, Stroke, Urgent Revascularization, and Rehospitalization for Ischemic Event
| WLW Marginal Regression Model of All Occurrences of Events | ||
|---|---|---|
| Parameter | HR (95% CI) | Pr>Chi‐Square |
| Vorapaxar effect on | ||
| First event | 0.924 (0.849 to 1.006) | 0.0695 |
| Second event | 1.001 (0.836 to 1.199) | 0.9892 |
| Third event | 0.901 (0.634 to 1.282) | 0.5635 |
| Fourth event | 0.618 (0.309 to 1.236) | 0.1737 |
| Fifth event | 0.272 (0.076 to 0.973) | 0.0452 |
| Sixth event | 0.000 (0.000 to 0.000) | <0.0001 |
| Seventh event | 0.000 (0.000 to 0.000) | <0.0001 |
| Eight event | 0.000 (0.000 to 0.000) | <0.0001 |
| Common vorapaxar effect across multiple events | 0.921 (0.837 to 1.012) | 0.0884 |
CI indicates confidence interval; CVD, cardiovascular death; HR, hazard ratio; MI, myocardial infarction; WLW, Wei, Lin, and Weissfeld.