Table 7.
Effect of Vorapaxar on Overall Occurrences of Composite TIMI Clinically Significant Bleeding Event
| WLW Marginal Regression Model of All Occurrences of TIMI Clinically Significant Bleeding Events | ||
|---|---|---|
| Parameter | HR (95% CI) | Pr>Chi‐Square |
| Vorapaxar effect on | ||
| First event | 1.427 (1.300 to 1.566) | <0.0001 |
| Second event | 2.428 (1.865 to 3.162) | <0.0001 |
| Third event | 3.207 (1.678 to 6.129) | 0.0004 |
| Fourth event | 8.050 (1.002 to 64.654) | 0.0498 |
| Fifth event | 3.049 (0.312 to 29.796) | 0.3379 |
| Sixth event | 0.000 (0.000 to 0.001) | <0.0001 |
| Common vorapaxar effect across all events | 1.550 (1.403 to 1.713) | <0.0001 |
CI indicates confidence interval; HR, hazard ratio; TIMI, Thrombolysis in Myocardial Infarction; WLW, Wei, Lin, and Weissfeld.