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Pretreatment with ISIS‐CRPRx attenuated endotoxin‐induced increase in CRP levels in a dose‐dependent and selective manner. (A) Maximum change in CRP levels by subject, (B) median change in CRP levels over time by treatment group, and (C) median change in SAA over time by treatment group, relative to preendotoxin baseline levels. CRP indicates C‐reactive protein; IQR, interquartile range; SAA, serum amyloid A.
