Table 3.
Comparison Between Baseline Characteristics and Kynurenine Pathway Metabolites in the Healthy Volunteers and in Patients Resuscitated From Cardiac Arrest
| Healthy Volunteers (n=10) | Cardiac Arrest Patients (n=245) | P Value vs Healthy Volunteers | ICU Survival (n=198) | P Value vs Healthy Volunteers* | ICU Death (n=47) | P Value vs Healthy Volunteers* | |
|---|---|---|---|---|---|---|---|
| Age, y | 63 (59 to 65) | 63 (56 to 72) | 0.86 | 63 (56 to 72) | 0.98 | 65 (59 to 75) | 0.437 |
| Sex, male, n (%) | 8 (80) | 197 (80.4) | 1.00 | 159 (80.3) | 1.00 | 38 (80.6) | 1.000 |
| TRP, μmol/L | 82.8 (70.0 to 89.0) | 39.5 (30.8 to 50.4) | <0.0001 | 40.1 (31.8 to 51.2) | <0.0001 | 37.1 (25.0 to 44.8) | <0.0001 |
| KYN, μmol/L | 2.4 (2.3 to 2.9) | 2.6 (1.8 to 3.5) | 0.624 | 2.4 (1.7 to 3.1) | 0.874 | 3.8 (2.5 to 4.5) | 0.003 |
| Ratio of KYN to TRP | 0.03 (0.027 to 0.034) | 0.064 (0.045 to 0.089) | <0.0001 | 0.059 (0.043 to 0.079) | <0.0001 | 0.095 (0.067 to 0.122) | <0.0001 |
| KYNA, nmol/L | 40.6 (32.5 to 60.3) | 52.8 (27.5 to 91.8) | 0.542 | 49.2 (26.7 to 83.6) | 0.794 | 90.6 (43.3 to 191.8) | 0.058 |
| 3‐HAA, nmol/L | 24.3 (18.1 to 27.8) | 28.1 (17.5 to 51.2) | 0.277 | 24.7 (16.7 to 42.4) | 0.519 | 54.6 (28.5 to 104.5) | 0.007 |
Data are reported as median (interquartile range) except as indicated. 3‐HAA indicates 3‐hydroxyanthranilic acid; ICU, intensive care units; KYN, kynurenine; KYNA, kynurenic acid; TPR, tryptophan.
* P considered significant if <0.025.