Table 5.
Independent Predictors of Levels of Kynurenine Pathway Metabolites
| Metabolite | Variable | β | P Value |
|---|---|---|---|
| TRP | Age | −0.539 | 0.640 |
| Sex (male) | 2.731 | 0.247 | |
| Shockable rhythm | 8.684 | <0.0001 | |
| BLS | −0.007 | 0.997 | |
| Adrenaline | −2.976 | 0.208 | |
| Time to ROSC | 0.659 | 0.629 | |
| KYN | Age | 0.417 | 0.002 |
| Sex (male) | 0.558 | 0.039 | |
| Shockable rhythm | −0.263 | 0.268 | |
| BLS | −0.428 | 0.057 | |
| Adrenaline | 0.653 | 0.016 | |
| Time to ROSC | 0.015 | 0.923 | |
| Ratio of KYN to TRP | Age | 0.264 | 0.0004 |
| Sex (male) | 0.179 | 0.233 | |
| Shockable rhythm | −0.506 | 0.0002 | |
| BLS | −0.244 | 0.052 | |
| Adrenaline | 0.395 | 0.0092 | |
| Time to ROSC | −0.014 | 0.875 | |
| KYNA | Age | 5.276 | 0.589 |
| Sex (male) | −9.476 | 0.634 | |
| Shockable rhythm | 40.29 | 0.022 | |
| BLS | −24.76 | 0.136 | |
| Adrenaline | 50.53 | 0.012 | |
| Time to ROSC | 2.037 | 0.859 | |
| 3‐HAA | Age | −0.024 | 0.994 |
| Sex (male) | −3.338 | 0.621 | |
| Shockable rhythm | −19.76 | 0.001 | |
| BLS | −3.005 | 0.592 | |
| Adrenaline | 5.981 | 0.376 | |
| Time to ROSC | 5.566 | 0.154 |
Multivariable linear regression model. 3‐HAA indicates 3‐hydroxyanthranilic acid; BLS, bystander‐initiated life support; KYN, kynurenine; KYNA, kynurenic acid; ROSC, return of spontaneous circulation; TRP, tryptophan.