Table 7.
Comparison Between the Basic Model and the Incremental Models With the Addition of Kynurenine Pathway Metabolites for Prediction of ICU Death and 12‐Month Poor Outcome
| ROC‐AUC | ΔROC‐AUC (SE) | P Value | cfNRI (SE) | P Value | |
|---|---|---|---|---|---|
| ICU death | |||||
| Basic model | 0.78 | ||||
| TRP | 0.78 | −0.001 (0.004) | 0.788 | 0.20 (0.16) | 0.21 |
| KYN | 0.83 | 0.046 (0.017) | 0.009 | 0.50 (0.16) | 0.002 |
| KYN to TRP | 0.81 | 0.023 (0.012) | 0.016 | 0.46 (0.16) | 0.005 |
| KYNA | 0.83 | 0.051 (0.021) | 0.015 | 0.54 (0.16) | 0.001 |
| 3‐HAA | 0.82 | 0.042 (0.020) | 0.037 | 0.65 (0.16) | <0.0001 |
| 12‐month poor outcome | |||||
| Basic model | 0.83 | ||||
| TRP | 0.84 | 0.003 (0.002) | 0.256 | −0.04 (0.13) | 0.738 |
| KYN | 0.84 | 0.005 (0.006) | 0.383 | 0.11 (0.13) | 0.392 |
| KYN to TRP | 0.83 | 0.000 (0.003) | 0.975 | −0.07 (0.13) | 0.588 |
| KYNA | 0.84 | 0.012 (0.008) | 0.114 | 0.26 (0.12) | 0.046 |
| 3‐HAA | 0.84 | 0.009 (0.007) | 0.212 | 0.31 (0.12) | 0.017 |
Δ indicates the difference in ROC‐AUC between the basic model and the model with the addition of kynurenine pathway metabolites; 3‐HAA indicates 3‐hydroxyanthranilic acid; cfNRI, category‐free net reclassification index; KYN, kynurenine; KYNA, kynurenic acid; ROC‐AUC, area under the receiver operating characteristic curve; TRP, tryptophan.