Table 1.

Studies Assessing the Association of Lower Extremity Performance Measures and Mortality in Patients With Peripheral Artery Disease

Study	Year	Country	NPAD	ABI	Claudicants	Follow‐Up (y)	NAC Mortality	NCV Mortality*	Assessment of Lower Extremity Performance
Jain et al8	2013	USA	442	—	—	4.71 (2.26 to 6.24)*	123	45	2‐y decline in WIQ distance, speed, and stair‐climbing scores
Leeper et al19	2013	USA	725	—	68.4%	11.3±6.3*	364	132	Customized symptom limited ramp treadmill protocol
Jain et al18	2012	USA	638	0.65±0.15*	32.0%	4.5*	221	78	WIQ distance, speed, and stair‐ climbing scores
McDermott et al21	2012	USA	434	0.63±0.2*	—	4.0±1.3*	103	35	Knee extension strength, knee extension power, and plantar flexion
McDermott et al20	2011	USA	440	0.66±0.15*	—	3.71 (2.17 to 6.08)*	102	39	Decline in 6‐min walk, fast‐paced, and usual‐ paced 4‐metre walking velocity
Singh et al24	2010	USA	410	—	—	5.0±1.9*	126	41	Isometric hip extension, hip flexion, knee extension, and knee flexion
de Liefde et al25	2009	Netherlands	1624	0.67±0.20*	—	5.0*	552	309	Treadmill total walking distance at 4 km/h
Sakamato et al23	2009	Japan	118	0.54±0.18*	100.0%	5.7±3.9*	33	16	Maximum walking distance; details not described
Gardner et al17	2008	USA	434	—	100.0%	5.1*	108	—	6‐min walk, WIQ distance, speed, and stair‐climbing scores
McDermott et al22	2008	USA	444	0.65*	—	4.81 (3.13 to 5.17)*	127	55	6‐min walk, fast‐paced and usual‐ paced 4‐metre walking velocity

ABI indicates ankle‐brachial pressure index; AC, all‐cause; CV, cardiovascular; N, number; PAD, peripheral artery disease; WIQ, walking impairment questionnaire; y, years.

^*Defined as death from coronary heart disease, stroke, peripheral vascular disease, and other cardiovascular disease in 8 studies. Defined as death from cardiac causes in 1 study.²⁵

^*Median and interquartile range. In some cases interquartile range was not provided.

^*Mean and standard deviation. In one case standard deviation was not provided.