Table 4.
Results of the joint longitudinal survival model (N=454) investigating the effect of retinal nerve fiber layer slope on the risk of development of visual field damage, while adjusting for confounding factors
| Longitudinal Submodel | ||||
|---|---|---|---|---|
| Coefficient | 95% CI | P | ||
| Intercept | 98.909 | 91.373 – 106.445 | <0.001 | |
| Time | 1.243 | 0.430 – 2.056 | 0.003 | |
| IOP | 0.031 | −0.281 – 0.343 | 0.846 | |
| Race(white) | −3.100 | −5.771 – −0.429 | 0.023 | |
| Age | −0.036 | −0.117 – 0.044 | 0.372 | |
| Baseline PSD | −5.144 | −8.669 – −1.618 | 0.004 | |
| CCT (centered around the mean) per 100 μm thicker | 2.100 | −0.500 – 4.800 | 0.117 | |
| Time*IOP | −0.111 | −0.144 – −0.078 | <0.001 | |
| Time*Race | 0.198 | −0.0420 – 0.437 | 0.106 | |
| Time*Age | −0.008 | −0.019 – 0.002 | 0.125 | |
| Time*Baseline PSD | −0.104 | −0.511 – 0.303 | 0.616 | |
| Time*CCT | 0.500 | 0.200 – 0.800 | 0.002 | |
| Survival Submodel | ||||
| Coefficient | 95% CI | P | Hazard Ratio | |
| Intercept of RNFL (μm) | 0.053 | 0.0220–0.085 | 0.001 | 1.05 |
| Mean IOP during follow-up (per 1 mmHg higher) | −0.032 | −0.157 – 0.093 | 0.618 | 0.97 |
| Race (ED vs AD) | −0.121 | −0.894 – 0.652 | 0.759 | 0.89 |
| Age (per 1 year older) | 0.027 | −0.007 – 0.060 | 0.121 | 1.03 |
| Baseline PSD, per 1 dB higher | 0.907 | 0.087 – 1.727 | 0.030 | 2.48 |
| CCT (per 100 μm thicker) | −0.500 | −1.400 – 0.500 | 0.314 | 0.61 |
| RNFL slope (per 1 μm/year faster) | 0.720 | 0.128 – 1.312 | 0.017 | 2.05 |
IOP: intraocular pressure, MD: mean deviation, CCT: central corneal thickness, ART: automatic real time function, GON: glaucomatous optic neuropathy, OHT: ocular hypertension, IOP: intraocular pressure, PSD: pattern standard deviation, ED: European descent, AD: African descent