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. 2015 Jan 29;11(1):e1004954. doi: 10.1371/journal.pgen.1004954

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© 2015 Luo et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Western blot analysis of wild type and Scml2 ^-/Y testes. (B) Dramatic testis weight reduction (per pair of testes) in Scml2 ^-/Y mice. (C) Sharp reduction in sperm count (per pair of cauda epididymides) in Scml2 ^-/Y mice. The body weight of age-matched male mice was similar. Body weight at the 2-month age: wild type, 28.0 ± 1.5 g and Scml2 ^-/Y, 28.6 ± 1.0 g (n = 3 per genotype). Body weight at the 8-month age: wild type, 39.4 ± 4.7 g and Scml2 ^-/Y, 39.3 ± 5.5 g (n = 3 per genotype). (D) Histology of a 4-month-old wild-type testis at low magnification. (E-I) Variable spermatogenic defects in tubules from 4-month-old Scml2 ^-/Y testes. Testis section is shown in low magnification (E). Spermatogenesis in some tubules (F) is relatively normal. Apparently apoptotic spermatocytes are indicated by arrowheads (G). A layer of lost spermatocytes is marked by a dashed line (H). Some tubules (I) exhibit nearly complete depletion of pachytene spermatocytes. Vacuoles are indicated by arrows (I). Abbreviations (F-I): Pa, pachytene spermatocytes; RS, round spermatids; ES, elongated spermatids. Scale bars, 50 μm.