Skip to main content
. 2015 Jan 29;10(1):e0116740. doi: 10.1371/journal.pone.0116740

Fig 7. Protein and amino acid metabolism in hypoxic GBM cells.

Fig 7

A-C, Hypoxic regulation of dipeptides (A), post-translationally modified amino acids (B) and acetylated amino acids (C) expressed as fold change in hypoxic vs. normoxic cells. D and E, Effects of hypoxia on the gamma-glutamyl cycle in GBM cells (D) and their conditioned media (E) compared with normoxic samples. F, Hypoxic effects on transcriptional activation of amino acid transporters expressed as fold change of mRNA levels at hypoxia vs. normoxia. G, Hypoxic modulation of amino acid catabolism in GBM cells. H, Schematic of arginine metabolism. I, Effects of hypoxia on arginine and related metabolites. J, Schematic of methionine and serine metabolism. K and L, Hypoxic modulation of methionine and its metabolites in GBM cells (K) and their conditioned media (L). M, Hypoxic effects on mRNAs of proteins involved in cysteine and glutathione synthesis. * P < 0.05; # 0.05 < P < 0.1. ADC, arginine decarboxylase; AGMAT, agmatinase; AMD1, adenosylmethionine decarboxylase 1; ARG, arginase; BHMT, betaine-homocysteine methyltransferase; CBS, cystathionine beta synthase; CTH, cystathionine gamma-lyase; DAO, diamine oxidase; GAMT, guanidinoacetate N-methyltransferase; GATM, glycine amidinotransferase; GCLC, glutamate-cysteine ligase; GSS, glutathione synthetase; NOS, nitric oxide synthase; OAT, ornithine aminotransferase; ODC, ornithine decarboxylase; SHMT, serine hydroxymethyltransferase.