Figure 10. Radial organization of the OT vasculature during DS6 (ED10, HH36).

(A: H-E; B: Diaphorase). (A) The TCC2 is no longer present because it delaminates into TCC4 -below TCC3-, C ‘‘h’’ and C ‘‘i-j”. The thickening of the OT cortex involves changes in the relative position of the different layers respect to each other and also respect to the original sites of lateral vessels origins. (B) The changes in the cortical organization are accompanied by sprouting of new branches at zones of high neuronal density and “pruning” of preexisting branches at zones of low neuronal density. Thin Arrows: lateral branches; arrowhead: radial vessel; dcv: descending branches; acv: ascending branches; thick arrows: periventricular plexus (Bars: 50 µm).