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. 2014 Dec 18;9(1):251–259. doi: 10.1021/nn504508s

Table 1. Relative Differences for RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles Described in This Work.

functional nanoparticle processed by Dicer stable in human serum activates type I IFNs activates pro-inflammatory cytokine activates RNAi
RNA–RNA nanocube YES NO YES YES YES
RNA–DNA nanocube NO NO YES YES NOa
DNA–RNA nanocube NO YES NO NO NOa
a

Cognate RNA–DNA hybrids are required for activation of RNAi during intracellular reassociation.