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Heterodimerization of GluN1 and GluN2 requires both coagonists. (A, B) SEDPHAT analysis of GluN1/GluN2A in the presence of both l-Glu and Gly (A) or l-Glu and d-Ser (B) fitted to monomer and dimer molar masses using a combined average molecular weight of GluN1 and GluN2A of 36 000. (C) c(M) distribution overlay showing attenuation of dimerization in the presence of DCKA compared to that in the presence of l-Glu/Gly.
