. 2014 Sep 2;26(2):328–338. doi: 10.1681/ASN.2013090990

Table 3.

Mitochondrial respiration (picomoles O₂ per second per milligram protein) during state 3 (active) and state 4 (rest), respiratory control ratio, and total leak respiration in the presence of ATP-synthase inhibitor oligomycin

Group	N	State 3	State 4	Respiratory Control Ratio	Total Leak Respiration	Leak Respiration through UCP-2	Leak Respiration through ANT	Total Regulated Leak Respiration
Control	10	121±19	23±3	5.1±0.3	28±2	0.2±0.3	1.6±0.3	1.8±0.4
Control+CoCl₂	7–9	114±17^a	19±3^a	5.9±0.4^a	23±2^a	0.3±0.3^a	1.5±0.3^a	1.8±0.5^a
Diabetes	9	265±29^b	34±3^b	7.8±0.6^b	43±5^b	5.4±0.6^b	5.6±1.1^b	11.3±1.6^b
Diabetes+COCl₂	9	167±11^a	22±2^a	7.4±0.3^b	24±2^a	0.2±0.2^a	1.6±0.1^a	1.8±0.2^a
Two-way ANOVA
Type		P<0.001	P=0.01	P<0.001	P=0.02	P<0.001	P=0.001	P<0.001
Treatment		P=0.02	P=0.01	P=0.66	P<0.001	P<0.001	P<0.001	P<0.001
Interaction		P=0.04	P=0.19	P=0.18	P=0.03	P<0.001	P=0.001	P<0.001

Involvements of UCP and ANT were determined by the magnitude of inhibition by the specific inhibitors guanosine diphosphate and carboxyatractylate, respectively. All values are ±SEM. Type denotes control versus diabetes, and treatment denotes untreated versus CoCl₂.

P<0.05 compared with the untreated diabetes group.

P<0.05 compared with the untreated control group.