Table 3.

Univariate and multivariate analyses of risk factors for death-censored allograft loss

Variable	Patients (n)	Univariate		Multivariate
		HR (95% CI)	P Value	HR (95% CI)	P Value
Clinicobiologic factors
Recipient sex
Female	27	1.00 (Reference)
Male	42	1.01 (0.49 to 2.08)	0.98		a
Recipient age (per 1-yr increment)	69	0.99 (0.96 to 1.01)	0.30		a
Retransplantation
No	45	1.00 (Reference)
Yes	24	1.02 (0.49 to 2.12)	0.95		a
Donor type
Living	4	1.00 (Reference)
Deceased	65	0.92 (0.22 to 3.91)	0.91		a
Donor age (per 1-yr increment)	69	1.00 (0.98 to 1.02)	0.87		a
No. of mismatches A/B/DR
≤3	20	1.00 (Reference)
>3	49	0.57 (0.27 to 1.18)	0.13		a
Cold ischemia time per 1-min increment	69	1.00 (0.99 to 1.00)	0.29		a
Estimated GFR at the time of rejectionb
≥30 ml/min per 1.73 m2	36	1.00 (Reference)
<30 ml/min per 1.73 m2	33	4.99 (2.12 to 11.70)	<0.001	3.56 (1.46 to 8.70)	0.005
Proteinuria at time of rejection
<0.3 g/d	32	1.00 (Reference)
≥0.3 g/d	37	2.82 (1.29 to 6.18)	0.009	—	NS
Histologic factorsc
Microvascular inflammationd
2 or 3	34	1.00 (Reference)
≥4	35	1.13 (0.55 to 2.35)	0.72		a
C4d graft depositione
0 or 1	26	1.00 (Reference)
≥2	41	1.45 (0.67 to 3.13)	0.34		a
Interstitial inflammation and tubulitis
0 or 1	27	1.00 (Reference)
≥2	42	0.95 (0.46 to 1.97)	0.90		a
Transplant glomerulopathy
0 or 1	49	1.00 (Reference)
≥2	20	1.24 (0.59 to 2.61)	0.57		a
Endarteritis (vasculitis)
0	54	1.00 (Reference)
≥1	15	0.92 (0.37 to 2.26)	0.85		a
Arteriosclerosis
0 or 1	52	1.00 (Reference)
≥2	17	0.72 (0.31 to 1.67)	0.44		a
Interstitial fibrosis and tubular atrophy
0 or 1	29	1.00 (Reference)
≥2	40	2.05 (0.91 to 4.62)	0.084	—	NS
Immunologic factors
C3d-binding DSA
No	29	1.00 (Reference)
Yes	40	4.35 (1.82 to 10.40)	0.001	2.80 (1.12 to 6.95)	0.027
MFI of the highest DSA
<6000	34	1.00 (Reference)
≥6000	35	2.47 (1.17 to 5.23)	0.018	—	NS
No. of DSA
1	38	1.00 (Reference)
≥2	31	1.67 (0.82 to 3.41)	0.16		a

^aThe variables that were not tested in multivariate model.

^bCalculated with the Modification of Diet in Renal Disease formula.

^cBanff scores (0: no significant lesion, 1: mild, 2: moderate, 3: severe).

^dSum of the Banff scores for glomerulitis and capillaritis.

^eData missing for 2 patients. Variables at P<0.1 in univariate model were incorporated into the multivariate model.