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. 2014 Jul 28;26(2):425–438. doi: 10.1681/ASN.2013111156

Figure 7.

Figure 7.

Na+ and K+ channel activity in the distal colon. (A) Ussing-type chamber experiments are used to record barium (Ba+)–sensitive K+ channel currents in the colonic mucosae isolated from AS+/+ and AS−/− mice after feeding either a control or a 2% K+ diet for 48 hours. (B) The barium-sensitive difference of ion currents are calculated and plotted as bar graphs. (C) Recording of amiloride (Amil) –sensitive Na+ channel currents on distal colon mucosae from AS+/+ and AS−/− mice kept either on a control diet or a 2% K+ diet for 48 hours. (D) The amiloride-sensitive differences of ion currents are calculated and plotted as bar graphs. n=5–6 mice per diet and genotype. Luminal concentrations are 5 mM for BaCl2 and 100 µM for amiloride. Values are the mean±SEM. *P≤0.05.