Table 1.
Baseline characteristics of 30 randomized patients and the subpopulation of 22 patients who received all study drugs
| Randomized Patients | Patients Who Received All Study Drugs | P Value | |
|---|---|---|---|
| n | 30 | 22 | |
| Age, yr | 39.9±13.5 | 40.6±12.4 | 0.79 |
| Body weight, kg | 66.8±13.2 | 68.6±13.2 | 0.67 |
| Body mass index, kg/m2 | 24.3±4.1 | 24.4±4.1 | 0.86 |
| Systolic BP, mmHg | 113±9 | 113±9 | 0.67 |
| Heart rate, beats/min | 67±10 | 66±10 | 0.92 |
| Plasma potassium, mmol/L | 2.8±0.4 | 2.8±0.5 | >0.99 |
| Plasma magnesium, mmol/L | 0.53±0.08 | 0.52±0.07 | 0.84 |
| Plasma sodium, mmol/L | 140.0±1.2 | 139.9±1.2 | 0.91 |
| Plasma creatinine, µmol/L | 57.7±14.6 | 63.6±17.0 | 0.80 |
| eGFR, ml/min per 1.73 m2 | 124±33 | 123±32 | 0.96 |
| Plasma renin concentration, mU/L | 89 (60 to 155) | 98 (49 to 162) | 0.99 |
| Plasma aldosterone, pg/ml | 44 (28 to 87) | 51 (28 to 87) | 0.88 |
| Urine sodium excretion, mmol/24 h | 186 [148–214] | 177 [148–211] | 0.68 |
| Urine potassium excretion, mmol/24 h | 108 [91–142] | 108 [91–134] | 0.86 |
| Urine magnesium excretion, mmol/24 h | 2.0 [0.9–3.3] | 2.8 [1.0–3.8] | 0.59 |
| Urine calcium excretion, mmol/24 h | 1.10 [0.49–1.85] | 1.21 [0.75–1.85] | 0.51 |
Data are mean±SD, geometric mean (95% CI), or median [interquartile range]. P values were by unpaired t test. Normal values for plasma renin concentration are 20.8 mU/L (95% CI, 17.7 to 24.4) in men and 16.2 mU/L (95% CI, 13.6 to 19.2) in women. Normal values for plasma aldosterone concentration are 45 pg/ml (95% CI, 39 to 52) in men and 34 pg/ml (95% CI, 28 to 40) in women. mU/L, milli-international units per liter.