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SETBP1 alterations and their proposed effects on myeloid cells. (a) SETBP1 alterations in myeloid malignancies affecting a specific putative degron in the SKI-homologous region of the protein. (b) Alterations lead to higher stability of the protein and, as a result, higher expression levels of the HOXA gene cluster as well as greater inhibition of PP2A action through the activity of the SET protein. WT, wild type.
