. Author manuscript; available in PMC: 2015 Jan 29.

Published in final edited form as: Am J Ophthalmol. 2013 Mar 14;155(6):971–982. doi: 10.1016/j.ajo.2013.01.020

Table 5.

Multivariable Longitudinal Mixed Effects Models Examining the Effect of Demographic and Ophthalmic Covariates on the Rate of Global Rim Area Change Over Time in the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study

			Main Effects

Multivariable Models	COVARIATES		TIME	COVARIATE	Association of covariates on the rate of rim area change (covariate * time)
#1	Randomization to Medication	Estimate	−0.0025	−0.0130	<0.0001
#1	Randomization to Medication	p-value	0.0011	0.6070	0.9270

#2	Race	Estimate	−0.0025	0.1534	−0.0007
#2	Race	p-value	<0.0001	<0.0001	0.3448

#3	Baseline Age	Estimate	−0.0011	−0.0023	<0.0001
#3	Baseline Age	p-value	0.4965	0.0962	0.3438

#4	Central Corneal Thickness	Estimate	−0.0026	0.0120	−0.0003
#4	Central Corneal Thickness	p-value	<0.0001	0.3358	0.1702

#5	Baseline Visual Field Pattern Standard Deviation	Estimate	−0.0026	−0.0116	−0.0009
#5	Baseline Visual Field Pattern Standard Deviation	p-value	<0.0001	0.1734	0.0001

#6	IOP as a repeated measure	Estimate	−0.0028	0.0061	−0.0017
#6	IOP as a repeated measure	p-value	<0.0001	0.0133	<0.0001

#7	Disc Area	Estimate	−0.0026	0.1647	−0.0009
#7	Disc Area	p-value	<0.0001	<0.0001	0.0005

#8	Standard Deviation of the Mean Topography as a repeated measure	Estimate	−0.0025	0.0014	−0.0008
#8		p-value	<0.0001	0.4728	0.0009

IOP = Intraocular Pressure