Table 6.

Global rate of change of topographic optic disc parameters by Ocular Hypertension Treatment Study Primary Open Angle Glaucoma status*: Univariate analysis

	Not at POAG endpoint (n=766 eyes)			POAG endpoint (66 eyes)			Difference between POAG and Non- POAG
	Mean	(95% CI)	p-value*	Mean	(95% CI)	p-value*	Mean	(95% CI)	p-value
	Rim area (mm2 /year)	−0.0026	−0.0036, −0.0015	<0.0001	−0.0131	−0.0174, −0.0089	<0.0001	−0.0105	−0.0149, −0.0062	<0.0001
Rim Area (%/yr)	−0.1723	−0.081, −0.1365	<0.0001	−0.8948	−1.1172, −0.6724	<0.0001	−0.7225	−0.9478, −0.4972	<0.0001
Rim to disc area ratio	−0.0013	−0.0019, −8 × 10−4	<0.0001	−0.0064	−0.0085, −0.0042	<0.0001	−0.005	−0.0073, −0.0028	<0.0001
Cup to disc area ratio	0.0013	8 × 10−4, 0.0019	<0.0001	0.0064	0.0042, 0.0085	<0.0001	0.005	0.0028, 0.0073	<0.0001
Mean cup depth (µm/yr)	0.0015	0.0012, 0.0017	<0.0001	0.0028	0.0018, 0.0039	<0.0001	0.0013	3.0 × 10−4, 0.0024	0.0156
RNFL thickness (µm/yr)	3.0 × 10−4	−1.0 × 10−4, 7.0 × 10−4	0.2018	−0.0012	−0.003, 7 × 10−4	0.215	−0.0014	−0.0033, 5 × 10−4	0.1369
RNFL cross sectional area (µm2/yr)	0.0014	−7.0 × 10−4, 0.0034	0.1852	−0.006	−0.0152, 0.0031	0.1954	−0.0074	−0.0167, 0.0019	0.1207
Cup Shape	0.0022	0.0018, 0.0026	<0.0001	0.0041	0.0024, 0.0059	<0.0001	0.0019	0.0001, 0.0037	0.0383
Rim Volume above reference (µm3/yr)	0.0023	0.0004, 0.0016	<0.0001	−0.003	−0.0062, 0.0002	0.0638	−0.0053	−0.0086, −0.0021	0.0013
Cup volume below surface (µm3/yr)	7.0 × 10−4	3 × 10−4, 0.001	<0.0001	0.0054	0.0039, 0.007	<0.0001	0.0047	0.0032, 0.0063	<0.0001
Glaucoma probability score (%/yr)	0.26	0.11, 0.42	0.001	1.49	0.77, 2.22	<0.0001	1.23	0.49, 1.97	0.0011

POAG = Primary Open Angle Glaucoma

RNFL = Retina Nerve Fiber Layer